Wondering What HypoThermosol and ATP Liposomal Spray Are?
What are they used for—and how do they help hair follicles?
One of the most critical goals in hair transplantation is achieving a natural-looking and dense result. However, there is one undeniable biological limitation that must always be considered: the donor area has a finite number of hair follicles. That’s why it’s not just important to use them wisely—but to ensure their maximum survival as well. Only then can the follicles fulfill their role in the recipient area: restoring density and coverage where thinning has occurred.
At Anastasakis Hair Clinic, our priority is to achieve outstanding, long-lasting results in every hair transplant procedure. For us, every single follicle counts—and is irreplaceable.
That’s why, in addition to precise planning and strategic placement, we place great emphasis on the survival and vitality of each transplanted hair follicle. Our goal is simple: to ensure the healthiest and fullest possible growth of every graft we transplant.
Tools like HypoThermosol and ATP Liposomal Spray play a key role in this effort—acting as the true “bodyguards” of the follicles throughout the entire process.
How Do Hair Follicles Survive Between Extraction and Implantation?
Preserving the viability of live tissues and organs during any type of transplant procedure has always been a significant challenge—until recently. This is especially true in hair transplantation, where hair follicles must remain alive and healthy as they are extracted from one area of the scalp and transplanted into another.
The most effective way to protect the follicles from external and environmental factors during this time is to store them in a chilled preservation solution.
At Anastasakis Hair Clinic, Dr. Anastasakis MD, PhD uses two advanced medical-grade solutions in every hair transplant procedure:
HypoThermosol® and ATP Liposomal Spray.
Both are clinically approved for the preservation of cells, tissues, and organs. They play a critical role in:
- Supporting optimal and healthy follicle development, and
- Promoting faster post-operative healing in the recipient area.
These solutions ensure that the hair follicles maintain their vitality during the transplantation process, maximizing the final outcome in terms of density, natural appearance, and long-term growth.
HypoThermosol® – The No.1 Hypothermic Cell, Tissue & Organ Preservation Solution
HypoThermosol® is a specialized, optimized hypothermic preservation solution designed to extend the viability of cells, tissues, and organs outside the body. Widely used in various fields of medicine—including heart, liver, and other organ transplants—it preserves biological structures at low temperatures, preventing cellular degradation while outside their natural environment.
Thanks to these properties, HypoThermosol® has recently found a valuable application in hair transplantation, offering a highly effective way to preserve delicate hair follicles between extraction and implantation.
How is HypoThermosol® used during a hair transplant?
Once the hair follicles are harvested from the donor area, they are immediately placed into chilled HypoThermosol® until they are re-implanted into the recipient area. This solution:
- Optimizes the cellular environment
- Increases the survival rate of the grafts
- Minimizes damage to these sensitive micro-organs during the out-of-body phase
Why don’t all clinics use HypoThermosol®?
To cut costs, many clinics use cheaper alternatives like saline or Ringer’s solution—or, in some cases, nothing at all. In these cases, survival rates can drop significantly, with only 70% or fewer grafts surviving the process.
At Anastasakis Hair Clinic, we follow the latest advancements in hair restoration and invest in the highest quality medical materials, including HypoThermosol®. Despite its higher cost, we consider it a critical investment—one that significantly enhances graft survival rates and speeds up post-operative healing in the recipient area.
What makes HypoThermosol® so effective?
According to its developers:
“HypoThermosol® contains ingredients that neutralize free radicals, regulate pH levels, support osmotic balance, and deliver vital energy substrates and ion concentrations. These factors help stabilize intracellular function at low temperatures.”
It also contains two powerful antioxidants—glutathione and a synthetic vitamin E analogue—which reduce molecular stress caused by cooling and rewarming during the transplant process. All of this contributes to increased graft viability, ensuring each follicle has the highest possible chance of healthy growth once implanted
Traditional vs. Modern Preservation: Why HypoThermosol® Outperforms Saline
For many years, hair transplantation techniques relied heavily on sterile saline solution as the preferred method for graft preservation. While saline effectively prevents dehydration, it offers no nutritional support to the follicular units once they are extracted from the scalp.
By contrast, modern biopreservation solutions like HypoThermosol®, especially when combined with ATP (adenosine triphosphate), provide the vital cellular energy and protection needed to keep hair follicles viable, healthy, and ready to thrive after transplantation
A key study (Cooley JE. Bio-Enhanced Hair Restoration. Hair Transplant Forum International. 2014;24(4):121, 128–130) tested graft survival after 96 hours outside the body, preserved either in saline or in HypoThermosol® with ATP. The results were clear:
Grafts stored in HypoThermosol® with ATP had significantly higher survival rates once implanted into the scalp.
This evidence reinforces the clinical importance of nutrient-rich, hypothermic solutions in maximizing graft yield and long-term transplant success.
ATP Liposomal Spray – The Power Bank for Your Hair Follicles
ATP Liposomal Spray is a groundbreaking innovation in post-operative hair transplant care. It not only enhances graft survival, but also significantly accelerates healing and recovery following the procedure—especially in FUE (Follicular Unit Extraction) cases, where grafts are thinner and more delicate.
ATP (Adenosine Triphosphate) is the primary energy source found in all living organisms. When metabolized by cells, ATP releases large amounts of energy, sustaining cellular activity and maintaining the health and viability of hair follicles.
What is Liposomal ATP?
Liposomal ATP is a solution that contains ATP encapsulated within liposomes—tiny lipid vesicles that act as biological carriers to deliver nutrients and energy directly into the cells. It is used both during the hair transplant procedure, while grafts are outside the body, and after implantation into the recipient area.
Following transplantation, the newly placed follicles are temporarily in a low-oxygen environment while new capillaries form. During this critical healing phase, ATP plays a vital role:
- It delivers immediate cellular energy to maintain follicle health.
- It acts as a potent vasodilator, increasing blood flow to the scalp and enhancing nutrient and oxygen delivery.
- The lipid vesicles serve as an ideal energy substrate for cell regeneration and proliferation.
At Anastasakis Hair Clinic
We include Liposomal ATP Spray as part of every patient’s post-operative recovery kit—provided completely free of charge. Under the guidance of Dr. Anastasakis, patients use the spray as directed to ensure maximum graft survival and optimal hair growth.
Key Benefits of Liposomal ATP Spray
- Energizes follicles, maintaining their health and viability immediately after implantation.
- Enhances scalp circulation by dilating skin arterioles, promoting faster follicular growth.
- Delivers essential nutrients via lipid vesicles, supporting rapid cellular regeneration.
At Anastasakis Hair Clinic, we believe that Liposomal ATP Spray is an essential post-op tool that not only maximizes the survival of transplanted grafts but also accelerates healing and improves the overall outcome of your hair restoration procedure.
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